Serious skin reactions eg, exfoliative dermatitis, SJS & TEN. Discontinue at 1st appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity. Increased risk of GI ulceration or other complications. New onset or recurrent CHF. Fluid retention, oedema & HTN. Pre-existing significantly impaired renal function, uncompensated heart failure, or cirrhosis. Patients w/ significant risk factors for CV events eg, HTN, hyperlipidaemia, DM, smoking; history of cardiac failure, left ventricular dysfunction, pre-existing oedema; dehydration. Monitor BP w/in 2 wk after initiation of treatment & periodically thereafter; renal function. May mask fever & other signs of inflammation. Rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption. Co-administration w/ warfarin or other oral anticoagulants; medicinal products known to inhibit COX/prostaglandin. May affect ability to drive & use machines. Discontinue if signs of hepatic insufficiency or persistently abnormal LFTs (3x ULN) occurs. Not recommended in women attempting to conceive. Pregnancy & lactation. Childn & adolescents <16 yr. Elderly.